Background & Aims: HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that constitutes the template for viral RNA and protein synthesis.Both HBx and HBc (core) viral proteins associate with cccDNA but, while HBx is required for viral transcription, the role of HBc is still unclear.The aim of
Background: The identification of suitable outcome measures will improve the evaluation of integrated NHS care for the large number of children affected by neurodisability, and has the potential to encourage the provision of more appropriate and effective health care.This research sought to appraise the potential of patient-reported outcome measure
The protozoan disease is a major global health concern.Amoebiasis, leishmaniasis, Chagas disease, and African sleeping sickness affect several million people worldwide, leading to millions of deaths annually and immense social and economic problems.Iron is an Watch Bands essential nutrient for nearly all microbes, including invading pathogens.The m
Abstract Background ANAT is a graphical, Cytoscape-based tool for the inference of protein networks that underlie a process of interest.The ANAT tool allows the user to perform network reconstruction under several scenarios in a number of organisms including yeast and human.Results Here Reusable Masks we report on a new version of the tool, ANAT 2.
In this review, we present evidence about the changes of the GABAergic system on the hippocampus under the ischemic environment, which may be an underlying mechanism to the ischemia-induced cognitive deficit.GABAergic system, in contrast to the glutamatergic system, is considered to play an inhibitory effect on the central nervous system over the p